Transthoracic Pulmonary Artery Denervation for Pulmonary Arterial Hypertension
نویسندگان
چکیده
منابع مشابه
Pulmonary Artery Denervation for Pulmonary Artery Hypertension.
W hile the seminal advance in the treatment of pulmonary artery hypertension (PAH) over the past 2 decades has been pharmacological targeting of dysfunctional endothelium-derived pathways that contribute to the characteristic vascular remodeling of this condition irrespective of etiology (1), several novel interventional techniques have also been useful in selected patients. Atrial septostomy, ...
متن کاملPulmonary Artery Denervation to Treat Pulmonary Arterial Hypertension
Methods O f a total of 21 patients with IPAH, 13 patients received the PADN procedure, and the other 8 patients who refused the PADN procedure were assigned to the control group. PADN was performed at the bifurcation of the main PA, and at the ostial right and left PA. Serial echocardiography, right heart catheterization, and a 6-min walk test (6MWT) were performed. The primary endpoints were t...
متن کاملPericardial effusion is correlated with clinical outcome after pulmonary artery denervation for pulmonary arterial hypertension
OBJECTIVES Pericardial effusion (PE) is correlated with outcomes in patients with pulmonary arterial hypertension (PAH). Pulmonary artery denervation (PADN) was used for treatment of PAH. The present study aimed to analyze the prognostic value of PE for outcomes after PADN in patients with WHO Group I, Group II and Group IV PAH. RESULTS PE, frequently seen in patients with connective tissue d...
متن کاملPulmonary Artery Denervation Attenuates Pulmonary Arterial Remodeling in Dogs With Pulmonary Arterial Hypertension Induced by Dehydrogenized Monocrotaline.
OBJECTIVES This study aimed to investigate sympathetic nerve (SN) ultrastructural changes and hemodynamic and pulmonary artery (PA) pathological improvements by pulmonary arterial denervation (PADN) in animals with pulmonary arterial hypertension (PAH), as well as the underlying mechanisms. BACKGROUND SN overactivity plays a role in PAH. Previous studies have reported short-term improvements ...
متن کاملPercutaneous pulmonary artery denervation completely abolishes experimental pulmonary arterial hypertension in vivo.
AIMS The study sought to assess the effect of percutaneous pulmonary artery denervation (PADN) on balloon-occlusion-induced acute pulmonary arterial hypertension (PAH) in vivo. The PADN is a minimally invasive and endovascular catheter-based interventional therapy using radiofrequency ablation to abolish the pulmonary arterial baroreceptors to pressure response. METHODS AND RESULTS To examine...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2019
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.118.311992